Olive leaf - A tool in the fight against cancer

Scientists have identified a new compound derived from olive leaf's oleanolic acid that protects against the development of liver cancer in laboratory animals. Both Liver and Breast cancers have been identified as responding to olive leaf. It is showing to be particularly effective in preventing cancers with a strong link to inflammation, such as liver, colon, prostate, and gastric cancers. A version of oleanolic acid, found in olive leaf, significantly reduced the growth of liver tumors in laboratory animals, according to researchers from Johns Hopkins University and Dartmouth Medical School. In their study, the use of small amounts of the olive leaf extract, a triterpenoid analog called CDDO-Im, yielded a greater than 85 percent reduction in the volume of liver tumors. Larger doses produced a 99 percent reduction. “Even at low-doses, CDDO-Im induces cell protecting genes, inhibits DNA damage by aflatoxin and dramatically blocks development of liver tumors,” according to Melinda Yates of Johns Hopkins University and lead author of the study. Experiments, led by researchers at the Johns Hopkins Bloomberg School of Public Health, show CDDO-Im to be effective at doses 100 times lower than other compounds known to prevent cancer in people. Because of its makeup, the researchers believe CDDO-Im could be particularly effective in preventing cancers with a strong link to inflammation, such as liver, colon, prostate, and gastric cancers. It could also play a role in preventing diseases such as neurodegeneration, asthma and emphysema. The olive fights breast cancer Laboratory results showing that oleic acid dramatically cuts the expression of a gene involved in the development of breast cancer have been acclaimed as a major breakthrough in understanding the benefits of the Mediterranean diet.

 Oleuropein Molecule      Hydroxytyrosol Molecule

The Olive and Cancer**

Some of the papers listed below focus on olive oil rather than fresh olive leaf complex but the papers are still listed here as the findings within the studies report the proven and potential health benefits of polyphenolic antioxidants such as oleuropein and hydroxytyrosol which are found in both olive oil and fresh olive leaf complex.

TITLE: The inhibitory effects of compounds from olive leaf on tumor necrosis factor production and on beta-hexosaminidase release.
AUTHOR: Nishibe-Sansei {a}; Han-Yingmei {a}; Noguchi-Yukari {a}; Ueda-Hiroshi; Yamazaki-Masatoshi; Mizutani-Kenji; Kambara-Toshimitsu; Kishida-Naoko
INSTITUTE: {a} Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan
SOURCE: Natural-Medicines. [print] August, 2001; 55 (4): 205-208.
YEAR: 2001

TITLE: The antioxidant/anticancer potential of phenolic compounds isolated from olive oil
AUTHOR: Owen-RW; Giacosa-A; Hull-WE; Haubner-R; Spiegelhalder-B; Bartsch-H
INSTITUTE: Division of Toxicology, Cancer Research Centre, Im Neuenheimer Feld 280, D-69120 Heidelberg
SOURCE: EUR-J-CANCER. European-Journal-of-Cancer. 2000; 36(10): 1235-1247
YEAR: 2000

TITLE: Antiatherogenic components of olive oil.
AUTHOR: Visioli,-F; Galli,-C
INSTITUTE: Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy. [email protected]
SOURCE: Curr-Atheroscler-Rep. 2001 Jan; 3(1): 64-7
YEAR: 2001

TITLE: Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.
AUTHOR: Fabiani, R 1; De Bartolomeo, A 1; Rosignoli, P 1; Servili, M 2; Montedoro, G F 2; Morozzi, G 1
SOURCE: European Journal of Cancer Prevention. 11(4):351-358, August 2002.
YEAR: 2002

TITLE: Tyrosol, the Major Olive Oil Biophenol, Protects Against Oxidized-LDL-Induced Injury in Caco-2 Cells
AUTHOR: C. Giovannini1, E. Straface*, D. Modesti, E. Coni , A. Cantafora, M. De Vincenzi , W. Malorni* and R. Masella
INSTITUTE: Department of Metabolism and Pathological Biochemistry, Department of Food and * Department of Ultrastructures, Istituto Superiore di Sanità, 00161 Rome, Italy
SOURCE: Journal of Nutrition. 1999; 129:1269-1277.
YEAR: 1999

TITLE: Olive oil, diet and colorectal cancer: an ecological study and a hypothesis.
AUTHOR: Stoneham M, Goldacre M, Seagroatt V, Gill L
SOURCE: J Epidemiol Community Health 2000 Oct; 54 (10): 756-60
YEAR: 2000

TITLE: Olive oil and colon cancer.
AUTHOR: Stoneham M, Goldacre M, Seagroatt V, Gill L
SOURCE: Health News 2000 Nov;6(11):8.
YEAR: 2000

TITLE: Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.
AUTHOR: Ragione FD, Cucciolla V, Borriello A, Pietra VD, Pontoni G, Racioppi L, Manna C, Galletti P, Zappia V
SOURCE: J Biochem Biophys Res Commun 2000 Nov 30; 278(3): 733-9
YEAR: 2000

TITLE: Olive oil: suitability for use as a vehicle in the local lymph node assay.
AUTHOR: Basketter DA; Kimberly I
SOURCE: Contact Dermatitis, 35(3): 190-1 1996 Sep.
YEAR: 1996

TITLE: Olive oil, other dietary fats, and the risk of breast cancer (Italy).
AUTHOR: la Vecchia C, Negri E, Franceschi S, Decarli A, Giacosa A, Lipworth L
SOURCE: Cancer Causes Control, 6(6):545-50 1995 Nov.
YEAR: 1995

TITLE: Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece.
AUTHOR: Trichopoulou A, Katsouyanni K, Stuver S, Tzala L, Gnardellis C, Rim, Trichopoulos D
SOURCE: J Natl Cancer Inst 1995 Jan 18;87(2):110-6.
YEAR: 1995

TITLE: Olive oil and breast cancer.
AUTHOR: Trichopoulou A
SOURCE: Cancer Causes Control, 196(6):475-6 1995 Nov
YEAR: 1995

** Olive leaf is not proven to prevent or treat cancer. These tests are exploratory in nature to show the connection between certain naturally occurring compounds and their effects on cancer cells. Further research is needed to conclusively determine olive leaf's benefits in the fight against cancer.

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